Sodium Hydroxide → HCID 178512102, compound

HRID 1382030Notes

Reaction equation

HRID 1382030 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].C[N:11](N=O)[C:12]([NH:14][N+:15]([O-:17])=[O:16])=N.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH:6][C:12]([NH:14][N+:15]([O-:17])=[O:16])=[NH:11]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 668533-FluorobenzylamineHCID 135436526N-Methyl-N'-nitro-N-nitrosoguanidine

Product 1

HCID 178512102HCID 178512102, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound m-fluorobenzylamine (7.5 g, 0.06 mol) is added to a slurry of N-methyl-N-nitroso-N'-nitroguanidine (8.33 g, 0.056 mol) in a 50% aqueous ethanol mixture. The thus-formed mixture is stirred for 18 hours, then treated with 1N NaOH (150 ml), and the mixture filtered. The filtrate is acidified with concentrated HCl, and the reaction mixture is then filtered to obtain the desired fluffy white solid product (10.6 g) having a melting point of 177° C.-179° C.

Workup

  1. filtrationthe mixture filtered
  2. filtrationthe reaction mixture is then filtered

Sources & evidence

ORD record
ord-63bf09b12f77415eafef28d2df235c01
Source dataset
uspto-grants-1989_02
Patent number
US04804780

Reaction notes

Loading…