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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1382053Generated: November 1, 2026

D-Norvaline → N-Cbz-norvaline amide

https://huagongshe.com/reaction/1382053

Reaction equation

Participants

RoleNameHCIDCharge
ReactantD-NorvalineHCID 439575—
ReactantZ-D-Nva-OHHCID 10106192—
ReactantHCID 178427886HCID 178427886—
ProductN-Cbz-norvaline amideHCID 86739099—

Reaction Steps

N-Benzyloxycarbonyl-D-norvaline (0.1 mole), prepared from commercial D-norvaline by the procedure of Example 19, is reacted with cis/trans 2,2,4,4-tetramethyl-3-hydroxycyclobutylamine by the method of Example 20, Part A, to provide the N-Cbz-norvaline amide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04804782
Source datasetuspto-grants-1989_02
ORD IDord-f345b596da6142f380bbfa46c7c1b0e4
Source noteuspto-grants-1989_02