Boron tribromide → HCID 13961780, compound

Participants

Reaction Steps

A mixture of 17.2 g (0.042 mole) of 1-(2,4-dibromo-5-methoxyphenyl)-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5-(1H)-one and 50.6 g (0.020 mole) of boron tribromide in 100 mL of methylene chloride was stirred at room temperature for 18 hours. The mixture was washed with 50 mL of water, and the organic phase was dried over anhydrous magnesium sulfate. This mixture was filtered, and the filtrate was evaporated under reduced pressure to yield 16.1 g of 1-(2,4-dibromo-5-hydroxyphenyl)4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5-(1H)-one as a solid.

Provenance & Evidence