Imidazole → HCID 14581296, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl-2-(4-fluorobenzoyl)benzoate (5.31 g, 21 mmol) in 23 mL of DMF is added dropwise to a solution of NaH (0.91 g, 23 mmol) and imidazole (1.43 g, 21 mmol) in 35 mL of DMF. The resulting mixture is heated at 120° C. for 20 hours under N2. After cooling, the product is poured onto ice and extracted with CHCl3 (4×30 mL). The combined extracts are dried (Na2SO4) and evaporated to give crude product. Chromatographic purification of the crude residue on silica gel (using EtOAc as the eluent) gives pure methyl-2-[4(1H-imidazol-1-yl)benzoyl]benzoate. M.P. 134.5°-136.5° C.

Provenance & Evidence