Diazomethane → HCID 14581289, compound

HRID 1382192Notes

Reaction equation

HRID 1382192 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[C:9]([C:14]([OH:16])=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[N+](=[CH2:21])=[N-]>>[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[C:9]([C:14]([O:16][CH3:21])=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 10014744HCID 10014744, compound

Product 1

HCID 14581289HCID 14581289, compound

Procedure

Treatment of 3-(4-fluorobenzoyl)pyridine-2-carboxylic acid with diazomethane, followed by silica gel chromotography (using hexanes-EtOAc (3:2) as the eluent), gives pure 3-(4-fluorobenzoyl)-2-carbomethoxypyridine.

Sources & evidence

ORD record
ord-d96ab622f47e476a8c7c537db22ccc72
Source dataset
uspto-grants-1989_02
Patent number
US04806535

Reaction notes

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