Imidazole → HCID 14581299, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-carbomethoxy-2-(4-fluorobenzoyl)pyridine (2.38 g, 9.18 mmol) in 7 ml of DMF is added dropwise to a mixture of NaH (0.25 g, 10.56 mmol) and imidazole (0.63 g, 9.18 mmol) in 25 mL of DMF. The mixture is heated at 120° C. for 20 hours, then allowed to cool, quenched with H2O and extracted with CH2Cl2 (4×50 mL). The combined organic layers are dried (Na2SO4) and evaporated to produce an oil. Chromatography on silica gel (using EtOAc-MeOH, 9.5:0.5 as the eluent) gives 2-[4-(1H-imidazol-1-yl)benzoyl]3-carbomethoxypyridine. M.P. 171°-173.5° C.

Provenance & Evidence