Imidazole → HCID 14581301, compound

Participants

Reaction Steps

A solution of 4-(4-fluorobenzoyl)-3-carbomethoxypyridine (2.05 g, 7.91 mmol) in 20 mL of DMF is added dropwise to NaH (0.37 g, 9.10 mmol) and imidazole (0.54 g, 7.91 mmol) in 35 mL of DMF. Using the same reaction conditions and workup as those used in Example 13, leads to the recovery of crude product. Chromatographic purification on silica gel (using EtOAc-MeOH, 95:5 as the eluent) gives pure 4-[4-(1H-imidazol-1-yl)benzoyl]-3-carbomethoxypyridine. M.P. 135°-137° C.

Provenance & Evidence