Ciprofloxacin → HCID 70393803, compound

Participants

Reaction Steps

3.3 g (10 mmol) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid are heated at 60° C. in 50 ml of dimethylformamide with 1.8 g (15 mmol) of allyl bromide and 2.1 g of triethylamine for 8 hours. The mixture is concentrated in vacuo, the residue is stirred with 30 ml of water and the precipitate is filtered off with suction, washed with methanol and dried. 2.2 g of 7-(4-allyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrobromide of melting point 295°-298° (with decomposition) are obtained; after recrystallization from water, 1.5 g of melting point 300°-302° (with decomposition) are isolated.

Provenance & Evidence