1-(Pyridin-3-yl)piperazine → HCID 21274457, compound

HRID 1382223Notes

Reaction equation

HRID 1382223 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:2]=1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=1)=[O:16]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:8][CH2:9][N:10]([CH2:14][C:15]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:21][CH:22]=3)=[O:16])[CH2:11][CH2:12]2)[CH:2]=1

Participants

3

Reactant 2

HCID 4372341-(Pyridin-3-yl)piperazineHCID 15592151N-(4-(2-bromoacetyl)phenyl)methanesulfonamide

Product 1

HCID 21274457HCID 21274457, compoundYield 60.4%

Procedure

Treatment of 1-(3-pyridinyl)piperazine (0.65 g) with N-[4-(bromoacetyl)phenyl]methanesulphonamide (1.17 g) according to the method of Example 1 gave the title compound, (0.90 g), m.p. 197°-198° C.

Sources & evidence

ORD record
ord-4662aeef1cd44bb8a0a674a0f9369587
Source dataset
uspto-grants-1989_02
Patent number
US04806536

Reaction notes

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