N-(4-(2-bromoacetyl)phenyl)methanesulfonamide → HCID 21274478, compound

HRID 1382224Notes

Reaction equation

HRID 1382224 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:19][CH:18]=1)=[O:16]>>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[CH2:12][CH2:11][N:10]([CH2:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([NH:23][S:24]([CH3:27])(=[O:26])=[O:25])=[CH:21][CH:22]=2)=[O:16])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 15592151N-(4-(2-bromoacetyl)phenyl)methanesulfonamideHCID 211890081-(1-Methyl-1H-imidazol-2-yl)piperazine

Product 1

HCID 21274478HCID 21274478, compoundYield 43.5%

Procedure

Treatment of 1-(1-methyl-2-imidazolyl)piperazine (0.37 g) with N-[4-bromoacetylphenyl]methanesulphonamide (0.64 g) according to the method of Example 1 gave the title compound, (0.36 g), m.p. 196°-197° C.

Sources & evidence

ORD record
ord-d53572d1c7c84fd7983760641d8d2d63
Source dataset
uspto-grants-1989_02
Patent number
US04806536

Reaction notes

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