HCID 21274532, compound → HCID 15697335, compound

HRID 1382231Notes

Reaction equation

HRID 1382231 reaction equation
C([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]1[CH2:18][N:19]([CH3:21])[CH3:20])C1C=CC=CC=1>C(O)C.[Pd]>[CH3:21][N:19]([CH2:18][CH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:16][CH2:17][NH:8]1)[CH3:20]

Participants

4

Reactant 1

HCID 21274532HCID 21274532, compound

Product 1

HCID 15697335HCID 15697335, compoundYield 98.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10.5 g of 2-benzyl-1-dimethylaminomethyl-1,2,3,4-tetrahydroisoquinoline were dissolved in 250 ml of 95% ethanol, 1.8 g of 5% Pd on charcoal were added, and the mixture was hydrogenated at room pressure and temperature for 4 hours. After filtration, and evaporation i.v., 7 g of product were obtained, sufficiently pure for the subsequent step.

Workup

  1. filtrationAfter filtration, and evaporation i.v

Sources & evidence

ORD record
ord-6014a59867fa4d46b1debb39c341dcea
Source dataset
uspto-grants-1989_02
Patent number
US04806547

Reaction notes

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