Dichloromethane → HCID 21274534, compound

HRID 1382232Notes

Reaction equation

HRID 1382232 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][NH:6]1)[CH3:3].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](O)=[O:24])=[CH:18][CH:17]=1.C1(N=C=NC2CCCCC2)CCCCC1.C(Cl)[Cl:42]>>[ClH:42].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([N:6]2[CH2:7][CH2:8][C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:5]2[CH2:4][N:2]([CH3:1])[CH3:3])=[O:24])=[CH:18][CH:17]=1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 10868DicyclohexylcarbodiimideHCID 74654Benzeneacetic acid, 4-bromo-HCID 15697335HCID 15697335, compound

Product 1

HCID 21274534HCID 21274534, compound

Procedure

Prepared as Ex. No. 1 by coupling 800 mg of 1-dimethylaminomethyl-1,2,3,4-tetrahydroisoquinoline and 1.05 g of (4-bromophenylaceticacid, dissolved in 35 ml of CH2Cl2, in the presence of 1.3 g of dicyclohexylcarbodiimide.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-16713f7fb201405faf56dba7e36bbf47
Source dataset
uspto-grants-1989_02
Patent number
US04806547

Reaction notes

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