2-Benzyl-1-(1-pyrrolidinylmethyl)-1,2,3,4-tetrahydroisoquinoline → 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

Participants

Reaction Steps

8 g of 2-benzyl-1-(1-pyrrolidinylmethyl)-1,2,3,4-tetrahydroisoquinoline were dissolved in 200 ml of 95% ethanol and hydrogenated on 1.5 g of 5% Pd on charcoal at 40° C. and room temperature. After 7 hr the catalyst was filtered off, and the solvent evaporated i.v. 5.5 g of crude product were obtained, sufficiently pure for the subsequent step.

Provenance & Evidence