HCID 13821494, compound → HCID 13821525, compound

HRID 1382242Notes

Reaction equation

HRID 1382242 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@H:15]1[NH:20][C:19](=[O:21])[C@@H:18]([CH2:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH3:32])[CH:24]=2)[NH:17][C:16]1=[O:33])=O)C1C=CC=CC=1>C(O)C>[NH2:11][CH2:12][CH2:13][CH2:14][C@H:15]1[NH:20][C:19](=[O:21])[C@@H:18]([CH2:22][C:23]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([CH3:32])[CH:24]=2)[NH:17][C:16]1=[O:33]

Participants

3

Reactant 1

HCID 13821494HCID 13821494, compound

Product 1

HCID 13821525HCID 13821525, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of (3R,6R)-3-(3-benzyloxycarbonylaminopropyl)-6-(1-methylindol-3-ylmethyl)piperazine-2,5-dione (1.2 g) in ethanol (240 ml) containing 10% paradium on charcoal (0.6 g) was hydrogenated at ambient temperature and atmospheric pressure. After catalyst was filtered off and solvent was evaporated, crude solid was taken up with ethanol, and dried in vacuo to give (3R,6R)-3-(3-aminopropyl)-6-(1-methylindol-3-ylmethyl)piperazine-2,5-dione.

Workup

  1. customwas hydrogenated at ambient temperature
  2. filtrationAfter catalyst was filtered off
  3. customsolvent was evaporated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-686950743c564c37bba9ca5a94c6e8b0
Source dataset
uspto-grants-1989_02
Patent number
US04806538

Reaction notes

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