HCID 178445048, compound → 3-hexanoyl-8-methoxy-4(1H)-quinolone

Participants

Reaction Steps

Ethyl 2-hexanoyl-3-(2-methoxyphenylamino)acrylate (18 g, 0.056 mol) was added in portions to boiling diphenyl ether (200 ml) and the mixture heated under reflux for 1 hour. After cooling, the mixture was diluted with petroleum ether, filtered and the solid washed with petroleum ether to give 3-hexanoyl-8-methoxy-4(1H)-quinolone (5.2 g, 33.8%), m.p. 169°-71° C.

Provenance & Evidence