HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-5-Methylaniline → 3-Butyryl-4-(2-methoxy-5-methylphenylamino)-8-methylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-5-Methylaniline | HCID 8445 | — |
| Reactant | 3-Butyryl-4-chloro-8-methylquinoline | HCID 10037627 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Butyryl-4-(2-methoxy-5-methylphenylamino)-8-methylquinoline | HCID 10066350 | 53.1% |
Reaction Steps
3-Butyryl-4-chloro-8-methylquinoline (1.77 g, 7.14 mmol) and 2-methoxy-5-methylaniline (1.47 g, 10.7 mmol) in dioxan (10 ml) were heated at reflux for 30 minutes, then evaporated and converted to free base. Recrystallisation from methanol and then from ethyl acetate/petroleum ether gave 3-butyryl-4-(2-methoxy-5-methylphenylamino)-8-methylquinoline (1.32 g), m.p. 136°-138°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806549 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-afc7fd84a7014cf9bff443999f0224a0 |
| Source note | uspto-grants-1989_02 |