反应详情

3-Benzoyl-4-chloro-8-methoxyquinoline (3.0 g, 0.01 mol) was heated under reflux in 1,4-dioxan (100 ml) with o-toluidine (5.0 ml) for 1 hour. The solvent was evaporated and the residue was dissolved in dichloromethane, and washed with dilute hydrochloric acid, sodium hydrogen carbonate solution, water and brine. The organic solution was dried and evaporated to an oil which was chromatographed (silic gel, 1% methanolic ammonia in dichloromethane). 3-Benzoyl-4-(2-methylphenylamino)-8-methoxyquinoline was isolated as crystals (0.95 g, 25.8%) from ether/hexane, m.p. 128-130.

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in dichloromethane
3. washwashed with dilute hydrochloric acid, sodium hydrogen carbonate solution, water and brine
4. customThe organic solution was dried
5. customevaporated to an oil which
6. customwas chromatographed (silic gel, 1% methanolic ammonia in dichloromethane)