反应详情

3-Butyryl-4-chloro-8-methoxyquinoline (20.2 g, 0.077 mol) and o-anisidine (15 ml, 0.11 mol) were heated under reflux in 1,4-dioxan (150 ml) for 1 hour. The solvent was evaporated and the residue dissolved in dichloromethane and washed with dilute hydrochloric acid, sodium bicarbonate solution and brine. The solution was dried, filtered and evaporated to a yellow solid, which was triturated with ether to give 3-butyryl-4-(2-methoxyphenylamino)-8-methoxyquinoline (18.55 g, 68.75%) m.p. 159°-161°.

1. customThe solvent was evaporated
2. dissolutionthe residue dissolved in dichloromethane
3. washwashed with dilute hydrochloric acid, sodium bicarbonate solution and brine
4. customThe solution was dried
5. filtrationfiltered
6. customevaporated to a yellow solid, which
7. customwas triturated with ether