HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroaniline → HCID 9997295, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroaniline | HCID 7240 | — |
| Reactant | 3-Butyryl-4-chloro-8-methylquinoline | HCID 10037627 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 9997295 | HCID 9997295 | 45.2% |
Reaction Steps
3-Butyryl-4-chloro-8-methylquinoline (2.48 g, 10 mmol) and 2-chloroaniline (1.6 ml, 15 mmol) in dioxan (10 ml) were heated at reflux for 30 minutes, then allowed to cool. The product was filtered off, converted to free base, and recrystallised from methanol to give 3-butyryl-4-(2-chlorophenylamino)-8-methylquinoline (1.53 g), m.p. 130°-131°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806550 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-4fedb07699c843c88150b3cb608e388d |
| Source note | uspto-grants-1989_02 |