Sodium Carbonate → HCID 14207120, compound

HRID 1382358Notes

Reaction equation

HRID 1382358 reaction equation
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[OH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:22][CH2:23][N:24]1[C:32](=[O:33])[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25]1=[O:34].C(=O)([O-])[O-].[Na+].[Na+]>C(C(C)=O)C(C)C>[OH:8][C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:9]1[CH2:14][CH2:13][N:12]([CH2:22][CH2:23][N:24]2[C:25](=[O:34])[C:26]3[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:32]2=[O:33])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 15723Azacyclonol

Product 1

HCID 14207120HCID 14207120, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

A mixture of 15 g (0.056 mol) of α,α-diphenyl-4-piperidinemethanol, 14.5 g (0.056 mol) of 2-(2-bromoethyl)-1H-isoindole-1,3-dione and 6.7 g (0.063 mol) of sodium carbonate in 150 ml of methyl isobutyl ketone is heated at reflux temperature for 5 hours.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature for 5 hours

Sources & evidence

ORD record
ord-d53c3a95b72548a1aeb480e7eee337c0
Source dataset
uspto-grants-1989_02
Patent number
US04806560

Reaction notes

Loading…