HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylonitrile → 3-{4-[Hydroxy(4-fluorophenyl)(2-pyridyl)methyl]-1-piperidyl}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | alpha-(4-Fluorophenyl)-alpha-(2-pyridyl)-4-piperidinemethanol | HCID 14698745 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-{4-[Hydroxy(4-fluorophenyl)(2-pyridyl)methyl]-1-piperidyl}propanenitrile | HCID 21274610 | — |
Reaction Steps
2.3 ml (0.035 mol) of acrylonitrile are added dropwise to a solution of 10 g (0.035 mol) of α-(4-fluorophenyl)-α-(2-pyridyl)-4-piperidinemethanol in 60 ml of ethanol and 1 ml of Triton B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806560 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-441cb37cc51b4e518ada73fc8c2f2f0d |
| Source note | uspto-grants-1989_02 |