Benzoyl chloride → HCID 21274608, compound

HRID 1382360Notes

Reaction equation

HRID 1382360 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:10]([C:13]1[C:14]([NH:19][CH2:20][CH2:21][CH2:22][OH:23])=[N:15][CH:16]=[CH:17][CH:18]=1)([O-:12])=[O:11]>N1C=CC=CC=1.C1C=CC=CC=1>[C:1]([O:23][CH2:22][CH2:21][CH2:20][NH:19][C:14]1[C:13]([N+:10]([O-:12])=[O:11])=[CH:18][CH:17]=[CH:16][N:15]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 7412Benzoyl chlorideHCID 21274601HCID 21274601, compound

Product 1

HCID 21274608HCID 21274608, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 1049PyridineSolvent

Procedure

70 ml of benzoyl chloride are introduced dropwise into a solution of 77.8 g (0.04 mol) of 3-[(3-nitro-2-pyridyl)amino]propanol (M. ISRAEL, N. TIROSH, J. Med. Chem. 1973, 16, 520) in 48.5 ml of pyridine and 800 ml of benzene. The mixture is stirred for 2 h at ambient temperature and the precipitate is filtered. The filtrate is washed with 1N hydrochloric acid and then with water. Drying, filtering and evaporation are carried out. A crystallized product is obtained.

Workup

  1. filtrationthe precipitate is filtered
  2. washThe filtrate is washed with 1N hydrochloric acid
  3. customDrying
  4. filtrationfiltering
  5. customevaporation
  6. customA crystallized product is obtained

Sources & evidence

ORD record
ord-922387bc3b984ebd97f99132cdc48413
Source dataset
uspto-grants-1989_02
Patent number
US04806560

Reaction notes

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