HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 1-Phenoxy-4-[4-(4-methoxyphenyl)-1-piperazinyl]-2-butanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-Methoxyphenyl)piperazine | HCID 269722 | — |
| Reactant | 4-Chloro1-phenoxy-2-butanol | HCID 13120342 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-Phenoxy-4-[4-(4-methoxyphenyl)-1-piperazinyl]-2-butanol | HCID 14422840 | — |
Reaction Steps
This compound was prepared according to the procedure of Example 78. A mixture of 4.8 g (0.025 mole) of 1-(4-methoxyphenyl)piperazine, 5.0 g (0.025 mole) of 4-chloro-1-phenoxy-2-butanol and 8.0 g (0.075 mole) of anhydrous sodium carbonate in 100 ml of 1-butanol gave 6.4 g (72%) of tan towder., m.p. 95°-97° C. Recrystallizing solvent used was isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806555 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-7867b88c664c4ae480c875aad1a4b6e5 |
| Source note | uspto-grants-1989_02 |