HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 19762408 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 12942344 | — |
Reaction Steps
1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (1.4 g.) (prepared by reacting 4-amino-1-(naphth-2-ylmethyl)piperidine with methyl isocyanate) in toluene (30 cm3) was acylated using benzoyl chloride (0.92 g) in presence of pyridine (0.6 g) to give the title compound: m.p. of HCl, hemihydrate salt=164°-166° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806552 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-2603e309a6194d66a31d405e57c38674 |
| Source note | uspto-grants-1989_02 |