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Hydrochloric Acid → Dimethenamid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 3-Thiophenamine, N-(2-methoxy-1-methylethyl)-2,4-dimethyl- | HCID 124089 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Cyclohexane ethylacetate | HCID 21867204 | — |
| 生成物 | Dimethenamid | HCID 91744 | — |
反応手順
0.02 Mol thionylchloride in 5 ml toluene are added dropwise, within 40 minutes, to 0.02 mol N-(1-methoxyprop-2-yl-)-2,4-dimethyltetrahydrothien-3-ylidenimine, dissolved in 10 ml of toluene at 20° . The reaction mixture is stirred for 2 hours whereby the hydrochloride of N-(-1-methoxyprop-2-yl)-2,4-dimethyl-3-aminothiophene is obtained. Then are added 0.02 mol of chloroacetylchloride dissolved in 5 ml toluene. This mixture is heated during 1 hour at reflux, whereby HCl escapes. The title compound is obtained by column chromatography on silica gel with cyclohexane/ethyl acetate (8:2), b.p. 148°-150°/0.03 Torr.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04806656 |
| 出典データセット | uspto-grants-1989_02 |
| ORD ID | ord-a2e0e55f28a6462ea7dc0372f2fbed8c |
| 出典メモ | uspto-grants-1989_02 |