Methyl iodide → N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-3-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-N-methylacetamide

HRID 13826Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[N:16][C:17]=2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[N:14]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:13](=[O:30])[C:12]([CH3:31])=[C:11]3[NH:32][C:33](=[O:35])[CH3:34])=[CH:4][CH:3]=1.I[CH3:37]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[N:16][C:17]=2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[N:14]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:13](=[O:30])[C:12]([CH3:31])=[C:11]3[N:32]([CH3:37])[C:33](=[O:35])[CH3:34])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 11466703N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-3-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]acetamide

Product 1

HCID 11203555N-[6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-3-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-N-methylacetamide

Procedure

Using the general procedure of EXAMPLE 12 the product of EXAMPLE 43 was reacted with iodomethane to afford the title compound. HPLC/MS: 542.2 (M+1), 544.2 (M+3); Rt=4.40 min.

Sources & evidence

ORD record: ord-a59829e84d4e43d7ab8ea49062aa77ef
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07728141B2

Reaction notes

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