2,2,2,4'-Tetrafluoroacetophenone → 1-Fluoro-4-[2-phenyl-1-(trifluoromethyl)ethenyl]benzene

Participants

Reaction Steps

4'-Fluoro-2,2,2-trifluoroacetophenone (F. E. Herkes et al.: J. Org. Chem. 32, 1311-18 (1967)) is reacted with benzyl-triphenyl-phosphonium chloride in the presence of an ethanol solution of sodium ethoxide. 1-Phenyl-3,3,3-trifluoro-2-(4-fluorophenyl)-propene is obtained with a yield of 91%; b.p.: 110°-114° C./0.2 mm Hg, m.p.: 43°-45° C.

Provenance & Evidence