Morpholine → HCID 53871710, compound

HRID 1382632Notes

Reaction equation

HRID 1382632 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)=[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([F:16])([F:15])[F:14])=[CH:7][CH:6]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[C:17]1([C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[C:8]2[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[CH:6][CH:7]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 54541849HCID 54541849, compound

Product 1

HCID 53871710HCID 53871710, compoundYield 92%

Procedure

3.25 g (7 mmoles) of 1-[4-(2-bromoethoxy)-phenyl]-2-phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene are reacted with morpholine as described in Example 1. The product is crystallized from hexane. 3.03 g (92%) of the aimed compound are obtained; m.p.: 95°-96° C.

Workup

  1. customThe product is crystallized from hexane

Sources & evidence

ORD record
ord-9ae5c7a306044f95b2027aa71597e259
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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