HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroacetophenone → 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroacetophenone | HCID 9905 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | (4-Fluorobenzyl)triphenylphosphonium chloride | HCID 2733554 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene | HCID 57056367 | 90% |
Reaction Steps
2,2,2-Trifluoroacetophenone is reacted with triphenyl-(4-fluorobenzyl)-phosphonium chloride (R. A. Jones: Australian J. Chem. 18, 903-6 (1965) in ethanol in the presence of sodium ethoxide. 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene is obtained with a yield of 90%; b.p.: 105°-107° C./0.2 mm Hg, m.p.: 35°-41° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806685 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-018a985c58db4b17bdd4b5052bf80006 |
| Source note | uspto-grants-1989_02 |