HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoro-4'-methoxyacetophenone → 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoro-4'-methoxyacetophenone | HCID 136555 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | (4-Fluorobenzyl)triphenylphosphonium chloride | HCID 2733554 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene | HCID 57217065 | 87% |
Reaction Steps
4'-Methoxy-2,2,2-trifluoroacetophenone (R. Fuchs: J. Org. Chem. 22, 993-994 (1957)) is reacted with triphenyl(4-fluorobenzyl)-phosphonium chloride (see Example 18) in ethanol in the presence of sodium ethoxide. 3,3,3-Trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propene is obtained with a yield of 87%; b.p.: 138°-142° C./0.5 mm Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04806685 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-277848f9c6df4b28b5bbffe0f636b73f |
| Source note | uspto-grants-1989_02 |