HCID 54412212, compound → HCID 53908471, compound

HRID 1382640Notes

Reaction equation

HRID 1382640 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][N:36]([CH3:38])[CH3:37])=[CH:29][CH:28]=2)=[C:16]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]([F:20])([F:19])[F:18])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)(=O)C.[Pd]>[CH3:38][N:36]([CH3:37])[CH2:35][CH2:34][O:33][C:30]1[CH:29]=[CH:28][C:27]([C:15]([C:12]2[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=2)=[C:16]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]([F:18])([F:19])[F:20])=[CH:32][CH:31]=1

Participants

4

Reactant 1

HCID 54412212HCID 54412212, compound

Product 1

HCID 53908471HCID 53908471, compoundYield 39.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

2.06 g (4.56 mmoles) of 1-(4-benzyloxyphenyl)-1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-3,3,3-trifluoropropene are dissolved in 45 ml of acetic acid and hydrogenated in the presence of 0.5 g of a 10% palladium-on-carbon catalyst. The solution is evaporated and the radius is crystallized from ether. 0.77 g (39.5%) of the aimed compound is obtained; m.p.: 149°-155° C.

Workup

  1. customThe solution is evaporated
  2. customthe radius is crystallized from ether

Sources & evidence

ORD record
ord-41dd79b7db6a49b2ba310cd2c1d9f46e
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

Loading…