Epichlorohydrin → HCID 21274937, compound

HRID 1382641Notes

Reaction equation

HRID 1382641 reaction equation
[OH-].[Na+].[O:3]1[CH:5]([CH2:6]Cl)[CH2:4]1.[C:8]1([CH:14]([C:27]2[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=2)[CH:15]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CO>[O:3]1[CH2:4][CH:5]1[CH2:6][O:33][C:30]1[CH:31]=[CH:32][C:27]([CH:14]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:15]([C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[C:16]([F:17])([F:18])[F:19])=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 21274916HCID 21274916, compound

Product 1

HCID 21274937HCID 21274937, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.8 g (20 mmoles) of sodium hydroxide and 14.8 g (160 mmoles) of 1,2-epoxy-3-chloropropane are added to a solution of 6.03 g (16 mmoles) of 1-phenyl-3,3,3-trifluoro-1-(4-hydroxyphenyl)-2-(4-chlorophenyl)-propane in 60 ml of methanol. The mixture is boiled for 2 hours and then processed as described in Example 25. The product is crystallized from methanol. 4.44 g (64%) of the aimed compound are obtained; m.p.: 141°-144° C.

Workup

  1. customThe product is crystallized from methanol

Sources & evidence

ORD record
ord-8ac914dd06944c94884a7d750bd36142
Source dataset
uspto-grants-1989_02
Patent number
US04806685

Reaction notes

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