Hydrochloric Acid → HCID 21274988, compound

Participants

Reaction Steps

20 g (0.15 moles) of anhydrous aluminium trichloride are added to a solution of 56.6 g (0.15 moles) of 1-bromo-3,3,3-trifluoro-1-(4-fluorophenyl)-2-(4-methoxyphenyl)-propane, prepared as described in Example 19, in 570 ml of anisol at 6° C. under stirring. The reaction mixture is allowed to stand at room temperature overnight, then it is poured into a mixture of 600 g of crushed ice and 100 ml of a 36% aqueous hydrochloric acid, and the resulting mixture is extracted with 500 ml of chloroform. The organic solution is washed with aqueous sodium hydrocarbonate solution and water, dried, and the solvent is evaporated. The dry residue is crystallized from 240 ml of isopropanol to obtain 34.6 g (57%) of 1-(4-fluorophenyl)-3,3,3-trifluoro-1,2-bis (4-methoxyphenyl)-propane; m.p.: 132°-135° C.

Provenance & Evidence