Bis(Chloromethyl) Ether → HCID 21274965, compound

Participants

Reaction Steps

9.6 g (120 mmoles) of chloromethyl ether and 8.4 g (210 mmoles) of powdered sodium hydroxide are added to a solution of 27.7 g (76 mmoles) of 2-phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-1-(4-hydroxyphenyl)-propane in 100 ml of benzene, prepared as described in Example 22, and the mixture is boiled for one hour. The reaction mixture is diluted with 150 ml of benzene, washed with a 20% aqueous ammonium chloride solution until neutral, dried and evaporated. The residue is dissolved in benzene and passed through a chromatographic column filled with 650 g of silica gel. The first eluate fractions are combined and evaporated to obtain 20.66 g (66.6%) of 2-phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-1-(4-methoxymethoxy-phenyl)-propane, which is applied in the subsequent step without purification.

Provenance & Evidence