Hydrochloric Acid → HCID 21273115, compound

Participants

Reaction Steps

2.8 g of lithiumaluminium hydride are added in portions, over a period of approximately one hour, to a solution, stirred under a nitrogen atmosphere, of 34.4 g of 6-(2-nonylphenyl)-5-hexenoic acid methyl ester (cf. EP-OL 0 123 543) in 300 ml of absolute tetrahydrofuran. After a further 10 minutes 30 ml of ethyl acetate and then 30 ml of water are added dropwise. The reaction mixture is acidified by the addition of 1N hydrochloric acid and extracted repeatedly with ethyl acetate. After the combined organic phases have been dried and concentrated by evaporation, the crude product that remains is purified by chromatography on silica gel with dichloromethane to yield the title compound in the form of a yellowish oil.

Provenance & Evidence