N-bromobutanimide → HCID 22841570, compound

Participants

Reaction Steps

A solution of 484 mg of 10β-(2-propynyl)-6-methylenestr-4-ene-3,17-dione in 20 ml of acetone is treated at room temperature with 312 mg of N-bromosuccinimide and 25 mg of silver nitrate, and stirred 4 hours at room temperature in the dark. The mixture is poured with stirring into ice-water and the formed precipitate is filtered off and dissolved in ethyl acetate. The resulting solution is washed with water, dried, evaporated to dryness in vacuo, and the crude is purified by flash chromatography on SiO2, eluting with n-hexane:diethylether 20:80 to give 363 mg of the title compound as a white crystalline product,

Provenance & Evidence