Chloranil → HCID 54166859, compound

Participants

Reaction Steps

A mixture of 313 mg of 10β-(3-bromo-2-propynyl)estr-4-ene-3,17-dione and 575 mg of chloranil in 21 ml of tert-butyl alcohol is heated at reflux for 2 hours. The mixture is diluted with ethyl acetate and filtered and the filtrate is washed with aqueous 1N sodium hydroxide, with brine and dried over sodium sulphate. The solvent is then evaporated and the residue chromatographed on silica gel using ethylacetate/n-hexane to give 140 mg of the title compound.

Provenance & Evidence