反应详情

Ethyl 2-(3-acetoxy-2-oxopropylthio)-6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate (3.54 g) was added to concd. sulfuric acid (35 ml) and the mixture was stirred at room temperature for 2 hours and 15 minutes. Thereto water (29 ml) was added gradually with ice-cooling and the mixture was stirred at room temperature for 26 hours, followed by addition of ice-water (400 ml). After precipitated crystal was filtered and washed with water, the resultant was recrystallized from a mixed solvent of chloroform - ethanol to give the title compound (2.38 g) as pale yellow crystals.

1. temperaturecooling
2. customAfter precipitated crystal
3. filtrationwas filtered
4. washwashed with water
5. customthe resultant was recrystallized from a mixed solvent of chloroform - ethanol