反应详情

Methyl 3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionimidate (8.68 g), ammonium chloride (1.74 g) and ethanol (60 ml) were stirred at room temperature for 4 hours. Ethanol was evaporated at reduced pressure and the residue chromatographed using silica gel and a chloroform-methanol gradient elution. Fractions containing the required product (as shown by TLC) were combined and solvent evaporated at reduced pressure to give 3-(4-dimethylaminomethyl-2-pyridylmethylthio)propionamidine hydrochloride (2.30 g).

1. customEthanol was evaporated at reduced pressure
2. customthe residue chromatographed
3. washa chloroform-methanol gradient elution
4. additionFractions containing the required product (as shown by TLC)
5. customsolvent evaporated at reduced pressure