Trityl chloride → (5-Methyl-1-trityl-1H-imidazol-4-yl)methanol

Participants

Reaction Steps

A solution of triphenylchloromethane (13.1 g) in dry DMF (80 ml) was added dropwise over 0.5 h to a stirred solution of 4-methyl-5-imidazolemethanol hydrochloride (7.0 g) and triethylamine (9.52 g) in dry DMF (75 ml) at room temperature under nitrogen, and stirring was continued for 2.5 h. The suspension was poured onto ice (600 ml), stirred for 0.5 h and filtered to give a solid (12.0 g). This solid was triturated twice with acetone (2×250 ml) to give the title compound (8.4 g) as a white solid, t.l.c. (System A 94.5:5:0.5), Rf 0.19.

Provenance & Evidence