反应详情

A mixture of 5-methyl-1-(triphenylmethyl)-1H-imidazole-4-methanol (4.0 g), manganese dioxide (activated) (40 g) and dioxan (225 ml) was stirred at room temperature overnight. The suspension was filtered through Hyflo, the solid washed with hot chloroform (1 l) and the combined filtrates evaporated in vacuo to leave an off-white solid (4.0 g). This solid was purified by FCC eluting with chloroform to give an off-white solid which was triturated with hexane (ca. 50 ml) to give the title compound (2.99 g) as a white crystalline solid, m.p. 184°-188° (decomp.).

1. filtrationThe suspension was filtered through Hyflo
2. washthe solid washed with hot chloroform (1 l)
3. customthe combined filtrates evaporated in vacuo