4-Toluenesulfonyl chloride → HCID 21273227, compound

Participants

Reaction Steps

Sodium hydrogen carbonate (9 g) was added to a stirred solution of 4-iodo-2-methyl-1H-imidazole (9.0 g) in acetonitrile (125 ml) followed by a solution of p-toluenesulphonyl chloride (8.3 g) in acetonitrile (50 ml). The resulting mixture was maintained at ca. 40° for 5 h. The reaction mixture was filtered, concentrated in vacuo to ca. 30 ml and n-hexane (ca. 350 ml) was added, precipitating the title compound (7.8 g) as crystals, m.p. 113°-114°. Concentration of the mother liquors (to ca. 50 ml) afforded further title compound (6.1 g), m.p. 112°-114°.

Provenance & Evidence