Triethylamine → HCID 21273214, compound

Participants

Reaction Steps

A mixture of 4-iodo-2-methyl-1-(4-methylbenzenesulphonyl)-1H-imidazole (3.62 g), N,N-dimethylacrylamide (1.05 g), palladium (II) acetate (125 mg) and triethylamine (2 ml) in acetonitrile (3 ml) was heated at 120° under nitrogen for 2.5 h. The cooled mixture waspartitioned between chloroform (3×50 ml) and 2N sodium carbonate (75 ml), and the combined organic layers were dried and evaporated in vacuo to leave a solid (ca. 3.0 g). This solid was purified by FCC eluting with chloroform to give the crystalline title compound (1.55 g), m.p. 162°-163°.

Provenance & Evidence