HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 5,6-Difluorooxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3,4-Difluoroaniline | HCID 77469 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,6-Difluorooxindole | HCID 12585282 | — |
Reaction Steps
Reaction of 3,4-difluoroaniline with chloral hydrate and hydroxylamine followed cyclization with sulfuric acid, in a manner analogous to Parts A and B of Preparation 9, gave 5,6-difluoroisatic, which was reacted with hydrazine hydrate followed by sodium methoxide in ethanol, in a manner analogous to Preparation 7, to give the title compound, m.p. 187°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04808601 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-138d68d43e9744c5b497d3c9563345d8 |
| Source note | uspto-grants-1989_02 |