Diethylamine → HCID 14054337, compound

Participants

Reaction Steps

The reaction is carried out as in Example 1, starting with 4-phenylbenzo[b]thiophene-6-carboxylic acid (4 g) and thionyl chloride (3.5 cc) in toluene (40 cc) and then adding triethylamine (13.25 cc) and diethylamine (1.6 cc) in toluene (40 cc). After chromatography of the residue on silica gel using a cyclohexane:ethyl acetate (50:50 by volume) mixture as the eluent and then stirring the product collected in 40°-60° petroleum spirit (30 cc) and filtering, N,N-diethyl-4-phenylbenzo[b]thiophene-6-carboxamide (2.55 g), m.p 60° C. is isolated.

Provenance & Evidence