Methyl iodide → HCID 14054339, compound

Participants

Reaction Steps

The reaction is carried out as in Example 2, starting with dimethyl sulfoxide (24 cc), potassium hydroxide powder (3.6 g), N-(1-methylpropyl)-4-phenylbenzo[b]thiophene-6-carboxamide (4 g) and methyl iodide (1.6 cc). After chromatography of the residue over silica gel using a cyclohexane:ethyl acetate (50:50 by volume) mixture as the eluent and recrystallization in isopropyl ether, N-methyl-N-(1-methylpropyl)-4-phenylbenzo[b]thiophene-6-carboxamide (1.2 g), m.p. 84° C., is isolated.

Provenance & Evidence