Piperidine → HCID 14054320, compound

Participants

Reaction Steps

The reaction is carried out as in Example 1, but starting with 7-phenylbenzo[b]thiophene-5-carboxylic acid (2.5 g) in toluene (25 cc) and thionyl chloride (2.2 cc) and then triethylamine (4.15 cc) and piperidine (0.97 cc) in toluene (25 cc). After two successive chromatographies of the residue on silica gel, the first with a cyclohexane:ethyl acetate (80:10:10 by volume) mixture as the eluent and the second with a cyclohexane:ethyl acetate (70:30 by volume) mixture as the eluent, a residue is isolated, which is stirred for 1 hour in 40°-60° petroleum spirit. After filtering and drying, 1-[(7-phenylbenzo[b]thien-5-yl)carbonyl]piperidine (1.55 g), m.p. 112° C., is isolated.

Provenance & Evidence