Ammonia → Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-

HRID 1382866Notes

Reaction equation

HRID 1382866 reaction equation
C([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[CH:9]=[CH:10][N:11](C)[CH3:12])=O.N>C(O)C>[CH3:14][N:7]1[C:8]2[CH:9]=[CH:10][N:11]=[CH:12][C:3]=2[C:4](=[O:17])[N:5]([CH3:16])[C:6]1=[O:15]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54245828HCID 54245828, compound

Product 1

HCID 3086912Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 1,3-dimethyl-Yield 84.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.47 g of 5-formyl-1,3-dimethyl-6-(2-dimethylaminovinyl)uracil was dissolved in ethanol, and ammonia was added thereto. The solution was stirred for 30 min at room temperature. The precipitated crystals were separated from the solution by filtration and recrystallized from ethanol to give 0.32 g of 1,3-dimethylpyrido[4,3-d]pyrimidine-2,4-dione (Compound 1).

Workup

  1. customThe precipitated crystals were separated from the solution by filtration
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-aae985345d584ab5a9e0c8b770495557
Source dataset
uspto-grants-1989_02
Patent number
US04808618

Reaction notes

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