Ammonium Hydroxide → Pyrido(4,3-d)pyrimidine-2,4(1H,3H)-dione, 5-amino-1,3-dimethyl-

Participants

Reaction Conditions

Reaction Steps

1.0 g of 5-cyano-1,3-dimethyl-6-(2-dimethylaminovinyl)uracil and 5.0 ml of 30% ammonia aqueous solution were added to 22.5 ml of DMF. The solution was heated at 100° C. in a sealed tube for 24 hr. The precipitated crystals were separated by filtration, washed with ether and recrystallized from ethanol to give 0.61 g of 5-amino-1,3-dimethylpyrido[4,3-d]pyrimidine-2,4-dione (Compound 3).

Provenance & Evidence