HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-[3-(Methylamino)propyl]benzthiazole dihydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate | HCID 53819401 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-[3-(Methylamino)propyl]benzthiazole dihydrobromide | HCID 21273462 | 93.1% |
Reaction Steps
1.7 g (4.99 mmol) of benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate are dissolved at 0° in 40% hydrogen bromide in acetic acid and stirred at room temperature for 20 hours. Thereupon, 60 ml of ether are added and, after 1.5 hours, the precipitate formed is filtered off. After washing the crystalline precipitate with ether and drying there are obtained 1.71 g (93.1%) of 2-[3-(methylamino)propyl]benzthiazole dihydrobromide, m.p. 196°-197°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04808605 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-42f63d39ede14e90ae2a9acd9c59d6b5 |
| Source note | uspto-grants-1989_02 |